Microencapsulation and
Microspheres
NEW Spherisator S Laboratory System
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Request for Lab System
Proposal:
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The Spherisator S is the ideal
microencapsulation and microsphere
forming laboratory system for small
scale trials and feasibility
studies and is powered by our patented
technology. |
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NEW Spherisator S
Like all of our Spherisators, the NEW
Spherisator S consists of an
external control box and a
vibrational microsphere and
microencapsulate drip forming
device. This is made of GMP/GLP-applicable
stainless steel (1.4571/AISI316Ti)
with an electropolished surface
finish. The control box of the
Spherisator S is available with a
Laptop with 15” screen size or as a
desktop PC with a separate 17” TFT
display. The control software is
part of the scope of delivery and is
pre-installed. It is also possible
to purchase the system without
computer and just the control
software in order to install it on
your own Laptop or desktop PC. We
can configure your the Spherisator S
to your specific requirements by
simply choosing separate standard
modules out of our wide range of
possibilities. The Spherisator S can
be operated using power supplies
delivering 230V / 50 Hz (e.g.
Western Europe) as well as using
power supplies delivering 115 V / 60
Hz (e.g. USA and Canada) or 100 V /
60 Hz (e.g. Japan). The Spherisator
S is designed to make microcapsules
and can be used to produce
microspheres as well. Microspheres
are solid spheres consisting of a
matrix, e.g. alginate, wherein
another substance is incorporated.
Microcapsules consist of a liquid or
solidified core which is surrounded
by a solid shell, e.g. alginate or
gelatin.
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Nozzles and Nozzle Heads
By the selection of the nozzle diameter
you can vary the diameter of the
microspheres and microcapsules which are
to be produced. As an order of magnitude
starting point, you can assume that the
diameter of the dripped microspheres to
be formed is approximately 1.89 times
the nozzle diameter. Melt point,
viscosity, and other physical properties
of the product to be formed into spheres
have to be taken into consideration when
selecting the appropriate nozzle
diameter(s).
We will be happy to help you
individually when selecting the ideal
nozzles for your process – please feel
free to contact us.
You can select your nozzles from the
following standard nozzles sizes:
- In the range from 50 to 500 µm
in steps of 50 µm
- In the range from 500 to 1000 µm
in steps of 100 µm
- In the range from 1000 µm to
6000 µm in steps of 200 µm.
- If you need a different diameter
which is not in this list, please
contact us for an individual quote.
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Feed Vessels
Our feed vessels with a usable volume
between 0.25 L and 5 L fit precisely
into the designated feed vessel holders
of the Spherisator S. They are delivered
with fittings, top cover, and clamping
ring. A feed tubing made of PTFE/PVDF,
in which the feed liquid is transported
from the feed vessel to the dripping
unit, is also part of the scope of
supply. The standard material of
construction for our feed vessels is
glass. As an alternative, you can order
feed vessels made of stainless steel.
For the stainless steel DIN
1.4404/AISI316L we offer also the
surface finish “electropolished”. |
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Reaction Vessel
When using a reaction vessel you can
collect the produced microspheres and
solidify them in this vessel.
Solidification in this case is done
chemically. For example, if alginate is
used as shell or matrix material,
solidification – and therefore the
stabilization of the perfectly spherical
shaped microencapsulates or
microspheres can be achieved by
dripcasting the granules into an aqueous
solution of CaCl2.
Our reaction vessels are available with
volumes ranging from 1 L to 5 L. As
vessel materials you can choose from
glass, PMMA, or stainless steel.
We also provide different types of
vessels with the most common being a
vessel with an integrated overflow that
can be used to keep the level of the
reaction fluid steady. Therefore, the
distance between drip forming nozzle and
reaction fluid level is kept steady.
The use of this type of reaction vessel
also results in longer production times
without the need to change the reaction
vessel. If the collecting solution is
stirred with a stirrer, the produced
microspheres are transferred more
rapidly from the surface – the
dripcasting area – to farther or lower
parts of the reaction vessel. This
reduces the risk of deformation and
coagulation which can occur through
direct contact of two or more not yet
solidified particles. A manual or
electrical elevation control system
allows for the adjustment of the
distance from nozzle and collecting
solution to an optimal value for your
individual dripcasting application.
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Vobis, LLC
provides fabrication, evaporation and granulation components,
and modular evaporation, granulation and pelleting systems. We
support our technologies with experienced engineering and
testing services.
Our fabrication services, evaporators, crystallizers,
distillation systems, multiple effect evaporators, falling film
evaporators, thin film, wiped film and short path evaporators,
extruders, pellet mills, spheronizers, and spray dryers have
proven themselves in multiple client applications. Our
formulation development and contract production services are
available for Evaporation as well as Microencapsulation,
Controlled Release Microsphere forming, and Granulation with Extrusion and Spheronization. |
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ASME
Fabrication, Evaporators, Thin- Film Evaporators, Ethanol Plant
Fabrication, Distillation Systems, Short- Path Evaporators,
Falling FIlm Evaporators, Multiple Effect Evaporators, Crystallizers, Solvent Recovery Systems,
Mixers, Extruders, Spheronizers, Fluid Bed Systems, Fluid
Bed Dryers
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Copyright Vobis LLC 2009. All Rights Reserved. Headquartered
in Easton, Pennsylvania |
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